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KMID : 1035320220490040213
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Korean Society for Dental Materials
2022 Volume.49 No. 4 p.213 ~ p.232
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Antibacterial effect of biodegradable gelatin methacryloyl loaded with ginger rhizome extract
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Trigueros Regina Guadalupe Arbizu
Kim Seo-Young
Kim Yu-Kyoung
Jang Yong-Seok
Choi Ae-Jin
Bae Tae-Sung
Lee Min-Ho
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Abstract
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Gelatin methacryloyl 3d mesh mimics the natural extracellular matrix which allow loading as promising drug delivery systems. However, insufficient mechanical and degradation properties remain the biggest obstacle for this material application. In this study, a modified hydrogel with natural phytochemical was developed to improve the antibacterial effect by the addition of ginger extract, a natural spicy used in traditional medicine. GelMA hydrogels with ginger extract were fabricated and their chemical and morphological characteristics were analyzed by Fourier transformer infrared spectroscopy and scanning electron microscopy, structural characteristic were evaluated by compressive test and surface wettability analysis. S. mutans, S. aureus and P. gingivalis were used to confirm the antibacterial effect of the modified hydrogels. The FT-IR spectra of the hydrogels modified with ginger presented an increase in intensity of some peaks in comparison with the 10% GelMA hydrogel. The pores of ginger-modified hydrogels decreased it size which affected the hydrogels physical properties, decreasing the compressive modulus and increasing the durability, swelling ratio and, hydrophobicity of the surface. The ginger-modified hydrogels exhibited excellent antibacterial properties against S. mutans and S. aureus at high concentrations of ginger extract, while P. gingivalis presented a higher sensitivity at all tested concentrations. Hence, this study concludes that ginger-modified GelMA hydrogels presented better antibacterial effect, durability over time and, swelling stability.
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KEYWORD
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Gelatin, Hydrogel, GelMA, Ginger extract, Antibacterial activity
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